immulivia-cordyceps-pure

Cordyceps Pure Natural Exract

Botanical scientific name:  Cordyceps (Ophiocordyceps) Sinensis, common names:  Caterpillar Mushroom, Caterpillar Fungus. Chinese name:  Dong Chong Xia Cao and Japanese name:  Tochukas. Hebrew names:  Cordyceps, the Chinese caterpillar fungus.

The Cordyceps fungus (Cordyceps Sinensis), also known as the Chinese caterpillar fungus, is first mentioned in the time of the Tang dynasty when there’s talk of a strange creature that lives in the high mountains of Tibet and is able to transform itself from an animal into a plant and back into an animal again.
It’s a parasitic fungus that grows in the high mountains of the Himalayas and other high mountains in Nepal, Tibet, and China.
The meaning of the Latin name: cord is a “stick”, and ceps is a “head”. There are hundreds of different species of mushrooms. It attacks various insects and grows from them or on their backs: ants, grasshoppers, cockroaches, bees, centipedes, beetles, and more.
The meaning of the Chinese name: The winter worm (transforms) into a summer plant.
The fruiting body of the Chinese caterpillar fungus sprouts from the caterpillar and looks like the caterpillar itself or like a thin 4-10 cm long stalk.

According to legend, the fungus was discovered by Yak herders who noticed that when the yaks were led to pasture in the high mountains of Tibet and Nepal in the spring when the snow melts, they dug up the ground and the last remnants of snow with their hooves, exposing fresh grass, and became very sexually active at that time.

They wondered what could cause the animals to increase their sexual activity.

Keen-eyed herders noticed that the yaks were exposing not only grass in their hooves but also a fungus that looked like a caterpillar. One brave shepherd decided to eat the mushroom and felt his libido and clarity of thought strengthened. His friends followed him and also tried to eat the mushroom.
They felt their stamina improve, their libido increase, and their energy levels rise. The rumor passed from mouth to mouth and it wasn’t long before news of the mushroom also reached the Chinese emperor and his doctors.

After they saw that it was good, the Chinese emperor coveted the mushroom and issued a royal decree forbidding the use of the mushroom outside the emperor’s court, and anyone who found this mushroom was ordered to bring it to the emperor.

The cordyceps mushroom is the most expensive mushroom in the world due to its rarity, and it was declared the “Emperor’s Mushroom”, due to its unique properties and the difficulties involved in finding it in nature.

Today, the mushroom is grown as a cultured mushroom, with the most studied strain and the one with the most important therapeutic properties being CS-4.

Activities are being researched

Broncho dilating activity, an activity that improves kidney function, apoptogenic activity, anti-inflammatory activity, antioxidant activity, an activity that improves peripheral blood flow, immunomodulatory activity (balances the immune system), antiviral and antibacterial activity, anticancer activity, an activity that improves sexual function, an activity that improves sports performance, hypoglycaemic activity, hypolipidemic activity, hypotensive activity (blood pressure balancing activity), thyroid balancing activity, hepatoprotective activity, prebiotic activity.

Labels backed by clinical studies for Cordyceps Sinensis:

Asthma, COPD, cough, pneumonia, kidney failure, immunodeficiency, viral and bacterial infections, cancer, stress, chronic fatigue (CFS), exhaustion and general weakness, type II diabetes, hyperlipidemia (excess fats in the blood), hypertension, improvement Sports performance, benign prostatic hyperplasia (BPH).

Traditional labels for which research evidence has not yet been found:

Impotence, lack of libido (lack of sexual desire), premature ejaculation, autoimmune diseases, attention deficit hyperactivity disorder, Hashimoto’s disease (autoimmune hypothyroidism), liver dysfunction, hepatitis, and thrombocytopenia.

In a traditional Chinese view:

Strengthens the Kidney Yang and nourishes the essence (Jing).

Nourishes and supports Lung Yin, stops bleeding, disperses moisture, and stops coughing.

Strengthens and supports the protective Qi (Wei Qi) and protects against the penetration of pathogens from the outside. Nourishes Yin and Liver Blood.

Safety, toxicity, interactions, and side effects of Cordyceps Sinensis:

Cordyceps mushroom is a safe mushroom to use.

  • Due to its immunostimulant activity, the mushroom should not be used for organ transplants.
  • You must stop using the mushroom five days before performing a surgical procedure and you can resume taking it two days after performing the procedure.

Cordycepin (the active substance in Cordyceps fungus) has been found to have anti-platelet adhesion activity. Since its quantity in a fungus is small, the clinical significance of this finding is not relevant.

  • There is no known danger of use during pregnancy.
  • There is no known danger of use during breastfeeding.

Cordyceps Sinensis active ingredients:

Cordyceps Sinensis Polysaccharides:

  • Exopolysaccharide fraction (EPSF)
  • Acid polysaccharide (APS)
  • Polysaccharide CS-F30
  • Polysaccharide CS-F10
  • Polysaccharide CPS-1
  • Polysaccharide CPS-2
  • polysaccharide CME-1
  • Polysaccharide CS-F10
  • Cordyglucans
  • Cordysinocan

Cordyceps Sinensis Monosaccharides:

  • Rhamnose
  • Ribose
  • Arabinose
  • Xylose
  • Mannose
  • Glucose
  • Galactose
  • Fructose
  • Sorbose
  • Mannitol
  • Cordyceptic acid
  • Monosaccharide saponins

Sterols:

  • Ergosterol
  • H1-A
  • glycoside derivatives of sterols
  • Nucleosides:
  • Cordycepin
  • 3′-deoxyadenosine

Polyamines:

  • spermine
  • Spermidine
  • Putrescine
  • 1,3-diaminopropane

Nucleotides:

  • uridine
  • Adenosine
  • Guanosine

Vitamins:

  • Vitamins from the B-complex family

Minerals:

  • Potassium
  • Sulfur
  • Phosphorus
  • Calcium
  • Magnesium
  • Manganese
  • Iron
  • Barium
  • Chromium
  • Boron
  • Zinc
  • Copper
  • Strontium

Fatty acids:

  • Oleic acid
  • Linoleic acid
  • Palmitic acid
  • Stearic acid
  • Docostatetraenoic acid
  • Lignoceric acid
  • Myristic acid
  • Behenic acid

Amino acids:

  • Tryptophan
  • Cystic acid
  • Aspartic acid
  • Methionine
  • Threonine
  • Serine
  • Glutamic acid
  • Proline
  • Glycine
  • Alanine
  • Valine
  • Isoleucine
  • Leucine
  • Tyrosine
  • Phenylalanine
  • Lysine
  • Histidine
  • arginine

Cordyceps Sinensis unique proteins:

  • Proteases
  • CSD Nase
  • Serine Protease CSP
  • Cordymin
  • Cordycedipeptide A
  • Cordyceamides A, B

Please contact us using the form below in case of order:

References:

Yu X, Ling J, Liu X, Guo S, Lin Y, Liu X, Su L. Cordecypin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells. Oncotarget. 2017 Jan 24;8(4):6691-6699. doi: 10.18632/oncotarget.14262.

Wang Z, Wu X, Liang YN, Wang L, Song ZX, Liu JL, Tang ZS. Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Molecules. 2016 Sep 27;21(10). pii: E1267.

Yoshida J, Takamura S, Yamaguchi N, Ren LJ, Chen H, Koshimura S, Suzuki S. Antitumor activity of an extract of Cordyceps Sinensis (Berk.) Sacc. against murine tumor cell lines. Jpn J Exp Med. 1989 Aug;59(4):157-61.

Nishizawa K, Torii K, Kawasaki A, Katada M, Ito M, Terashita K, Aiso S, Matsuoka M. Antidepressant-like effect of Cordyceps Sinensis in the mouse tail suspension test. Biol Pharm Bull. 2007 Sep;30(9):1758-62.

Li SP, Zhang GH, Zeng Q, Huang ZG, Wang YT, Dong TT, Tsim KW. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine, 13(6), 2006, 428–433.

J Altern Complement Med. 2002 Jun;8(3):315-23. A fermentation product of Cordyceps Sinensis increases whole-body insulin sensitivity in rats. Balon TW, Jasman AP, Zhu JS.

Kiho T, Yamane A, Hui J, Usui S, Ukai S. Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps Sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull 1996; 19: 294–6.

Liu Y, Wang J, Wang W, Zhang H, Zhang X, Han C. The Chemical Constituents and Pharmacological Actions of Cordyceps Sinensis. Evid Based Complement Alternative Med. 2015; 2015:575063. doi: 10.1155/2015/575063. Epub 2015 Apr 16. Review.

Li S, Tsim KWK. The Biological and Pharmacological Properties of Cordyceps sinesis, a Traditional Chinese Medicine That Has Broad Clinical Applications. Oxidative stress and disease. 2004;14:657–684.

Ng TB, Wang HX. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005 Dec;57(12):1509-19. Review.

Zhou X, Gong Z, Su Y, Lin J, Tang K. Cordyceps fungi: natural products, pharmacological functions and developmental products. J Pharm Pharmacol. 2009 Mar;61(3):279-91. doi: 10.1211/jpp/61.03.0002. Review.

Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ. Antiaging effect of Cordyceps Sinensis extract. Phytother Res. 2009 Jan;23(1):116-22. doi: 10.1002/ptr.2576.

HJ Cho,  JY Cho ,  MH Rhee , HJ Park. Cordycepin (3′-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. European journal of pharmacology, 2007

Tsai YJ, Lin LC, Tsai TH. Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps Sinensis in rats. J Agric Food Chem. 2010 Apr 28;58(8):4638-43. doi: 10.1021/jf100269g.

Yu HM, Wang BS, Huang SC, Duh PD. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J Agric Food Chem. 2006 Apr 19;54(8):3132-8.

Yue GG, Lau CB, Fung KP, Leung PC, Ko WH. Effects of Cordyceps Sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells. J Ethnopharmacol. 2008 Apr 17;117(1):92-101. doi: 10.1016/j.jep.2008.01.030. Epub 2008 Feb 6.

Guan J, Zhao J, Feng K, Hu DJ, Li SP. Comparison and characterization of polysaccharides from natural and cultured Cordyceps using saccharide mapping. Anal Bioanal Chem. 2011 Apr;399(10):3465-74. doi: 10.1007/s00216-010-4396-y. Epub 2010 Dec 9.

Li SP, Yang FQ, Tsim KW. Quality control of Cordyceps Sinensis, a valued traditional Chinese medicine. J Pharm Biomed Anal. 2006 Aug 28;41(5):1571-84. Epub 2006 Feb 28.

Yu L, Zhao J, Li SP, Fan H, Hong M, Wang YT, Zhu Q. Quality evaluation of Cordyceps through the simultaneous determination of eleven nucleosides and bases by RP-HPLC. J Sep Sci. 2006 May;29(7):953-8.

Zhou X, Luo L, Dressel W, Shadier G, Krumbiegel D, Schmidtke P, Zepp F, Meyer CU. Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis. Am J Chin Med. 2008;36(5):967-80.

Wang Z, Li N, Wang M, Wang Y, Du L, Ji X, Yu A, Zhang H, Qiu F. Simultaneous determination of nucleosides and their bases in Cordyceps sinensis and its substitutes by matrix solid-phase dispersion extraction and HPLC. J Sep Sci. 2013 Jul;36(14):2348-57. doi: 10.1002/jssc.201300204. Epub 2013 Jun 21.

Zhang L, Dai X, Xu F, Wang F, Gong B, Wei Y. Preparation of imidazole-functionalized silica by surface-initiated atom transfer radical polymerization and its application for hydrophilic interaction chromatography. Anal Bioanal Chem. 2012 Sep;404(5):1477-84. doi: 10.1007/s00216-012-6210-5. Epub 2012 Jul 8.

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